Guild Wars 2

There have been ideas in the past about making nourishments easier to handle, such as a UI button that you drop your food into so you can easily click to use instead of opening inventory, but a lot of that seems focused around how food tends to run out without being noticed by people.
My suggestion would be to simply make the nourishment icons flash slightly for the last 10 seconds of their span before they go away. Not a flash similar to what currently happens with buffs, but a glowing flash around the icon. Something different to catch the peripheral vision when you are focused on the game.

Would this be too annoying?

I think they are already selling the Metabolic Primer for this sort of issue.