Currently Running Sigil of Earth, Sigil of Corruption for P/P Elixir Gun build, 10/30/0/30/0
Also running full set of Runes of the Undead, they balance out my Carrion Armor nicely for both Vit and Toughness.
I am curious though if giving up the toughness for Bleed Duration/Condition Duration Runes, along with Power Sigil would be better DPS for the build.