1440p?
It isn’t especially optimised for it, no. OTOH, I play it at 2560 × 1440 without any particular issues, so you should be fine on a 27" or so display…
UI looks to be scaled for 1080p but 1440p might be fine on a big enough display. 2160p seems to be an issue from many.
RIP City of Heroes
I have a 27" 1440P monitor and don’t have any issues with the UI. It did feel small when the monitor arrived (Since I was used to a 23" 1080P monitor) but after a day or two I got used to it and now it’s great. Interface size is set to normal
The game is all right at 1440P if you have a beefy enough GPU. You’re CPU limited a lot of the time anyways, so the biggest time it will hold you back is in the open world. I usually sit at ~55-65FPS in the open world with reasonably high settings.
All of this being said, it would be worth looking at a 480 if you’re considering a 1060, which card is better pretty much comes down to which games you play
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