Your frustration with clicking on all skils is understandable. But there are ways around it as Laurie wrote.
I have remapped 1-5 on Q, E, R and C.
Picking up things is under F, but ELite is under Shift+F.
The F1-F4 skills are remaopped to Shift Q, Shift E, Shift R etc.
Now I also use a Logitec G602 mouse that has 6 thumb buttons, but also a clickable scrollwheel and two DPI buttons. So the THumb buttons use heal, dodge, utilities, weapon swap.
Once I configured this way, playing the game became a whole lot more intiutive, giving me more focus on gameplay rather than looking at the keyboard to find the right keys or spending time moving the mouse.
But you could do without such a mouse. You can also combine some of the functions to ALT+[key] to control the utilities.
THe only thing that will be weird at first is that you looose track of all where each skill is. But after a while you’ll get used to it and it becomes part of you.