With Valve pushing hard for Linux gaming, and DOTA having a client in Linux, I think a Native Linux Client for Guild Wars 2 could be a big thing.
You already have a client for Mac, if that’s worth doing, why not for Linux?
A client that could run natively in my Ubuntu rig would be awesome. It’s true that the WinE guys have been able to make it run under Linux, but you need the compatibility layer and even when the result is playable, there are a certain number of issues with WinE (no support for multithreading, which leads to abnormally low FPS sometimes, is the most annoying one).
Everytime a linux gamer has to run WinE for playing, Grenth kills a baby Quaggan. And if he has to keep a dual boot with Windows, Grenth kills two baby quaggans each time he switches OS. Think of the little baby quaggans!