Guild Wars 2

There are a few sets of Runes with -condition duration. I think theres a set with -15% and -20% duration.

If Agony is a condition like Anet has said. Will these runes work?

-20% duration is technically 20% less damage. That’s pretty significant.

This would completely remove the need for ascended items, so no, it does not work.
Also, contemplation of purity, guardian’s passive condition removal, any other condition removal skills do not remove agony, so its not a condition.