By Any Other Name...
It depends on what that new setting is. I play RPGs, MMO and otherwise, for the lore as much as, if not more than, the gameplay and it’s almost always the lore that first gets me interested in a game.
I think the gameplay is good enough that it’d make a great game with different lore, but the lore needs to be up to scratch too. I’ve seen several games where the developers made the mistake of thinking it doesn’t matter, you throw together some vaugely fantasy related things, say some big evil is attacking the world and as long as combat is fun you’ve got a great RPG and it just doesn’t work that way for me.
“Life’s a journey, not a destination.”
Nope. I play games first and foremost for the story. If there was a game without any progression at all, just exploration and narrative, it would become my all time favorite instantly.
Although GW2s lore is a lot shallower and less morally ambiguous than its predecessor, its still an interesting world that allowed me to dive in and enjoy myself for as long as I could find any information with substance.
I’m not playing the game anymore (for actual gameplay reasons), so I would definitely not want to play a product with identical game mechanics with a different skin slapped on.