Guild Wars 2

Hello

I have tons of obsidians shards, spirits shards, bloostone dust, dragonit ore, empyreal fragments.
How should I use them to make money?

‘make money’ ? They are account bound. As is pretty much everything you can make out of it.(not everything maybe but you know what I mean)
You can use ‘pets’ like princess or mawdrey to consume some of it, the rest is best used with:
right click->destroy->confirm

If you’re not going to use them for crafting or to give to one of the “eaters” then delete them. You’ll get more.

Level one of the many crafting professions and if you have anything mats left do some research and see what you can sell.