Guild Wars 2

make holding a button (like ctrl) and clicking the left mouse button work like double-clicking. That way you only have to click half as many times when you are clicking away on a large stack of items.

Alt+Shift+NumLk for mouse keys then press 5 and + to click.

thats a strange thing to do. what and how ever you do that.

Alt+Shift+NumLock toggles the “mousekeys” feature, and you can use numpad 5 or numpad + instead of clicking.
Then you can toggle it off when you’re done.

Edit: I just tried this. I thought key repeat would kick in and help. But that doesn’t seem to happen. So you’re just pounding a key on the numpad instead of a button on your mouse. The scroll wheel suggestion here might be more useful:
https://forum-en.gw2archive.eu/forum/game/gw2/Extend-your-mouse-s-life/5115495