Guild Wars 2

I use A, S and D to Strafe Left, Move Forwards and Strafe Right, respectively. My weapon skills are mapped from Q to T, Utility Skills to Z, X and C, Heal and Elite to Mouse Buttons 4 and 5, and finally Profession skill are 1-4.

This setup brings all the skill keys close to my movement keys and I can still circle strafe and launch skills at the same time.

Bloodlust.3672:

the problem with that is you still have to lift your fingers off from movement buttons when activating skills

But putting your hotkeys comfortably -- for you, as what is comfortable may differ from person to person, so I won’t claim where I have mine is optimal -- around your movement keys is a solid approach. You cannot move backwards and forwards at the same time, nor can you move left and right at the same time. So potentially you have a couple fingers on that hand that should be able to hit your hotkeys without disrupting your movement. Or, at least, disrupting it a minimal amount.