Dungeon Multiple Runs?
Hobby Dungeon Explorer on very fast paths, maybe.
Other than that, not really, no.
You only get the bonus chest containing 40 tokens and 1-3g once per day, so ye, I also chose to do paths only once a day. You still get some rewards from running a path twice (20 tokens, bit a silver from drops/end-chest and a lot of experience) but I find it more profitable to do a lot of different quick paths.
I did rush a toon to 80 by doing AC over and over, once I hit the right level I farmed SE p1 and after CoF p1, but it was only efficient because I had 4 amazingly lovely people coming along to rush me to 80 and thus Fractals. About a level per run. Money-wise it wasn’t worth it.