Higher Visibility Pointer?
on your mac: go to System Preferences / Universal Access / Mouse. slide the Cursor Size selector to the right. I have mine at about 1.75 times normal size, which is enough to see it easily in high activity parts, but not so much that it covers stuff and makes it hard to see where you are selecting. btw, this will affect your in-game cursor and out-of-game cursor equally.
if you have a pc: pretty sure you’re sol.
Mystic’s Gold Profiting Guide
Forge & more JSON recipes
https://github.com/fritzw/gw2-cursor
Generic disclaimer about not being supported by Anet. Not my program, but it does seem to work very well.
This is a small script that draws a larger cursor on the screen while GW is running and makes it much harder to lose in the clutter of battle. It is only a large arrow, it doesn’t change to any of the dynamic cursors like the targeting reticle and such, but you should still have that in game.
Related reddit post:
http://www.reddit.com/r/Guildwars2/comments/1i2pgg/i_hate_losing_my_mouse_pointer_in_hectic_battles/