Guild Wars 2

With this rig , on max settings:
Intel i5 3450 3.1ghz turbo boost 3.5ghz
EVGA GeForce GTX670 FTW 2048MB
MOBO Intel B75 Express Chipset
Monitor is 1600×900

first off all your not telling your regular ram. secondly your windows version has influence as well.

But given the specs your are stating it should run fine, maybe some minor performance issues in big zergs like wvw or dragonfights but i dont think so. Even if this is the case, it is a few clicks to go to minimum settings for a few minutes