Antitoxin in PvP?
Ask the devs. They wanted to bring in Runes of Perplexity instead of every other rune that could possibly not blow up the meta.
I make guides to builds you may not have heard of;
http://www.youtube.com/user/ceimash
http://www.twitch.tv/ceimash
http://www.youtube.com/user/ceimash
http://www.twitch.tv/ceimash