As seen in the recent stream that showcased the camera changes, you can see that there is an indication for when you can use skills and not have them target nearby enemies.
Using the current camera, the only option is to have auto-targeting turned off if you would like to use a movement based skill without the chance of it targeting something else. And as said in the stream, auto-targeting can be very helpful especially against stealth-based professions.
Can we please get a modifier key that makes skills ignore all targets? E.g. Holding shift while using the Guardian’s Leap of Faith causes it to ignore all nearby enemies and go in the direction you are facing.