might building with FT
No, you just have 30% less boon duration since boon duration is not tied to the alchemy line anymore, and since deadly mixtures is not there, you also have no reason to go into this line per default with flamer.
However, one of the minors in alchemy will give you 20% boon duration back, but even then you still miss out on 10% compared to pre-patch.
Running HgH and E-gun will fix that for you, tho.
You can get your crit chance back by taking the bottom first two traits in Inventions. It will give you 50% uptime of vigor (if you have alchemy), 10% on nearby foes and 10% on bleeding foes. Combine that with bleed on crit (minor) and additional bleed durration (also a minor, and you should have 20-40% additional crit chance to proc your Sigil (remember it have an ICD).
Also, since you are going into alchemy, invest in HgH with elixir gun as Arantheal said.