So I may be late to the party, but I just found out about autohotkey and how it makes it possible (and “legal”) to assign keys to mouse-wheel up/down. I have mine set-up to punch virture of justice on scroll down, but of course you may use any skill you want just by changing the appropriate script (zoom will still function). Just follow the simple instructions on making a new folder and voila!
#IfWinActive, Guild Wars 2 ahk_class ArenaNet_Dx_Window_Class
Wheeldown:: ; Proffesion skill 1
{
Send {Wheeldown}
Send {F1}
}
Return
Neenu Waffler-Warrior for what once was the Toast-