Which Runes? Mesmer PvE -
it depends on that you are condition damage or interrupt duration or critical damage or normal damage.
No there is no “consensus”, but i simply use this rule. What “special” effects can a rune set(1-6) or multiple 1-2 rune sets give me. If i just want the stats, i just put crests in my armor+jewelery, since its 288 total stats vs 211 + a effect.
As tip all the duration % runes and “on crit” runes are nice, since its hard to get this via traits or other means.
As example, u can get +45% bleed duration via 3 different sets, which on a condition build will outperform any other thing u can put in.
The boon duration runes are also very strong, since it allows u to stack might boons faster.
So try find effects, which u normally have no access to or hard to get otherwise. For me runes are defined by there effects and not stats, thats where i would use crests over runes.
I also don’t like the often noted “+10 stat 2% crit” set, since i normally dont care about the 3 stats i don’t use and having +60 vitality in a PvE power/crit build does nothing.