Which runes...
Because of the fact that no one can inspect other players in this game. I have taken the liberty of becoming a rune addict. I sometimes switch mine out to different runes and combinations 3 or 4 times a night. Sometimes I will go for condition damage + vitality or toughness. Sometimes I will go for precision or different effects. the cost of runes on the TP is relatively low in my opinion, so take advantage of that fact and mix and match them and try them all. shrug.