just look at the reaper and omg
spite, death magic and reaper – you can bunker with -10% dmg if foe is poison and -10% if chill, along side weakness and some protection and you are hard to kill
spite, soul reaping and reaper – great killing machine with great dmg modifiers , protection and migh gaining (which heals you bit)
spite, blood, reaper – again good dmg and siphon abilities