Guild Wars 2

If you have 1 set as your auto- attack and use assassians signet, does the auto attack count towards the next hit, or a skill you physically activate?

Assassin’s Signet works on the next skill, not hit. It’s bugged → activating Haste will use up Assassin’s Signet’s active component.

Whatever skill-bar action you do after activating the signet will use up the charge, whether you press the button or if your character does it.