For probably a year now the combination “Allow skill retargeting” and “Instant ground targeting” is nearly impossible to play. The problem is, that skill retargeting is extremely useful for longer cast times, i.e. if your target gets killed or goes into stealth you can switch to another one. But if I use ground targeting skills, its problematic, because any mouse movement leads to a new ground targeting position.
There was a short period of time between the introduction of the setting “Allow skill retargeting” (everything worked well) and a patch that changed things to this situation.
I hope there can be a solution to this, maybe another sub setting to make it possible to play with this combination again.