Guild Wars 2

Seemingly randomly my ability to click monsters or players to target them stops working. Tab targeting still works. I can fix it by resetting the game. Any idea what causes this or am I hitting some weird hotkey I don’t know about?

Seems to happen to me quite often due to alt-tabbing.

I’m not sure if this plays into as well or not, but I also play windowed fullscreen, not fullscreen mode.