Guild Wars 2

When using Eyefinity in mixed rotation P.L.P my mouse disappears in the game it still can select and use all my buttons but its invisible.

It works in Windows mode and Windowed Fullscreen at the same resolution that covers everything( called Manual PLP), but then I can’t use AMD Crossfire.

I’ve opened my mouse options in control panel it is set to default with no tails checked or anything weird.

My Specs
Windows 10 Pro 64 bit
GW2 64 bit Client
i5-6600k
Gigabyte Z170X-Gaming 3
32gb ram (4 x8 sticks) CL14 DDR4 2133MHZ
MSI R9 380 (all monitors hooked on to this) (DP, HDMI, DVI)
MSI R9 380 (sitting idle cause of no crossfire)

Researched Sources

http://plp-gaming.wikia.com/wiki/Special:Search?search=disappearing+mouse&fulltext=Search

https://community.amd.com/message/2656690
http://www.wsgf.org/forums/search.php?keywords=mouse&t=29079&sf=msgonly

Any assistance that you can provide would be appreciated.