I can't finish the Tier 1.
I have a similar problem. While I was fighting Masticus in tier 2 Salazan suddenly appeared so I had to fight both of them at the same time. I killed Salazan before Masticus and the match ended, apparently now I can’t challenge Masticus anymore since I never actually defeated him and just moved up in bosses.
Yep I had the exact same problem I skipped the end boss of tier 1 and all bosses except the pirate in tier 2.