I have middle mouse button set to dodge. I have removed the double move keybinding for dodge. This usually works fine. However twice in combat I have found that my other keys and mouse clicks seem to be working but middle mouse button no longer does anything in GW2. I can tab out to windows and the middle mouse button still works there.
The problem persists in and out of combat. However if I go to the options/controls page and save the settings again (i.e close the page without making changes) the middle mouse button again works and performs the dodge.