Guild Wars 2

I often find GW2 minimizing itself in the heat of combat.

Factors influencing this are:
1) I run a dual-screen setup. The second screen is unused by GW2.
2) I have Free-Look enabled, and often rotate the camera independently of my character sometimes (usually to kite while nading)
3) This causes me to use LMB (left mouse button) if I want to change direction to where i’m looking and RMB if I want to rotate the camera without changing direction yet.

I can reliably cause GW2 to minimize by doing the following things:
1) Hold RMB, rotate camera
2) While still rotating camera while holding RMB, hold LMB, release RMB, keep moving mouse while still holding LMB.

This will ‘unstick’ the mouse’s location and allow it to wander into an adjacent monitor. Clicking after the mouse pointer has wandered into an adjacent monitor will cause GW2 to minimize.

I guess it would be more clear to say it this way:
Hold RMB, Hold LMB, Release RMB, Move mouse in the direction of your other screen. The mouse pointer will show up on the empty screen.

I have the same issue. It gets really annoying in WvW.