As I was redoing out of the shadows on an alt, I noticed that the NPC’s (Rytlock, Caithe, etc.) do nothing when in combat, though all works fine with dialog etc.
As soon as the combat starts they do not fight, do not get aggro, do not take damage, do not heal the player when downed (even if you literally lay inside of them, involuntarily ended up confirming it was not a matter of distance) and do not move.
At times even the White Mantle enemies do nothing as well. Only saw this doing Justiciar Adrienne as 3 of them stood around Rytlock and did nothing unless I actually ran into them.
However I did see a few irregularities. In ‘A shadows deeds’ Caithe at one point suddenly decided to attack a little, a few pistol rounds then went back to standing still.
In ‘Confessors stronghold’ doing the first couple of vet bloodstone elementals and Justiciar Adrienne Canarch was fighting properly, but at Jade Construct he too did nothing.