Alt(windows key)-Tab closes the Game
Are you sure that the client is not being minimized, rather than closed? While in full-screen, pressing Command+Tab (Windows+Tab with a PC keyboard) should minimize the game, then holding Command and pressing Tab several times should cycle through the open applications, allowing you to bring Guild Wars 2 back up.
I am pretty sure but unfortunately I can’t double check as it won’t load after showing a black screen and then closing the program now.