Guild Wars 2

I get critical Errors all the time. Needed to reinstall GW2 because it crashed everytime i clicked “Play” in the Launcher.
Now while playing GW2 crashes approx every hour in different locations. This is one of the latest Errors, I’ll paste the next ones too. Playing on Windows 7 64bit

—> Crash <—
Assertion: Failed to load file.
File: ..\..\..\Services\Asset\AssetPc.cpp(346)
App: Gw2.exe
Pid: 2600
Cmdline:
BaseAddr: 01390000
ProgramId: 101
Build: 53415
When: 2015-09-24T20:44:22Z 2015-09-24T22:44:22+02:00
Uptime: 0 days 3:39:55
Flags: 0

EDIT: Everytime I try to repair the game, it freezes and I have to ctrl+alt+del

I would check my harddisk first :
http://www.howtogeek.com/134735/how-to-see-if-your-hard-drive-is-dying/

Also look into the windows system logs if they show errors, could also be just
a defect SATA cable.