Same issue for me using a Logitech M510 laser mouse. No SetPoint installed, using standard Windows 7 drivers. I am currently working around the issue by using a junky lenovo wired optical mouse…it’s slow as molasses, but at least I can turn without having to re-click/hold the RMB 4-6 times, or watch the cursor jump around. The M510 works fine with the OS as well as other games (MMO & FPS), issue only appears when GW2 is running.
Dual screen DVI in windowed fullscreen mode on an ATi HD 5970 with the latest catalyst drivers. Win 7 Pro 64-bit.