I came from using wow for 3.5 years where everything is customizable, and while I appreciate that part of WoW, I enjoy not having to worry about it. That being said, the biggest boss I have fought so far was the FIRST dragon in the story mode. So I may eventually get annoyed by it.
I’d say that my biggest complaint is a lack of online access to my auctions/auction house. And a lack of any sort of character view outside of the game. This is ONE area that Blizz has ANet beat. Battle.net is awesome for those who cannot play all day but want to make some gold off of auctions.