I’m having the same problem as Wolfies. I’m running on an older system (Windows XP with Phenom II X4 @ 3 Ghz, 4GB RaM, AND GTX 260 core edition).
However, the game ran great up till the Lost Shores update. Since then it gets a complete black screen with flickering and mouse lag when it starts up. Then crashes my computer with BSOD. Computer will then be stable after a restart. This is definitely frustrating as I can’t play at all now.