I’ve been running Staff/SB with Zerk armor, and runes of the brawler. I feel like the runes give enough toughness to help you sustain a bit longer in a fight, but not lose out on damage. I run Weakening Strikes, Staff Master and Bound, with Fist Flurry and Impact Strike, and i really love being able to hop around, with a consistent 10% damage increase, but not really have to worry about dying instantaneously.