I’m only lev 60, and i’m proceeding along the game at a measured pace, but i have had absolutely no problem dying with greatsword+rifle, all-signets build (with +40 Precision from each sig). I dodge out of fire/big attacks, but otherwise just stand there and take it with my GS out. If i fall below 1/3 hp or so, i switch to rifle and kite until i feel comfortable enough to continue melee. I do make sure to update my gear every 3-4 levels, so that might also be making a difference.