Sorry I’m late to the party!
On my thief I typically move using just the mouse with the middle mouse button for auto run. As a previous League of Legends player I’m used to using QWE and R for attacks so I bonded the 1-4 abilities there. I keep my 5th skill on D with steal on F so I can quickly use the Cloak and Dagger/steal combo. I have my utilities on 1-4 and my elite skill on v just because. I also use my pinky to either hit caps lock to switch between enemies, tab to interact, or shift to jump, and keep my thumb on the space bar for dodging or slide over to alt to talk to my homies in Team Speak.
The only downside that I’ve found with this set up is that jumping puzzles are crazy hard with mouse only movement (especially with my awful internet.)