I believe I’ve had this problem too.
So far It’s only occurred in the Harathi Highlands when fighting the boss in the last Modir event.
It doesn’t always happen, but when it does my headset basically loses all volume
and all I hear is a loud “WOO, WOO” sound coming from the left speaker.
Even when I tab out, (yes I have the setting to mute game sound when tabbed) it still goes on until the
game crashes.
It’s pretty weird, is this somewhat like what you’re having an issue with?
(Also I have random sound spikes for certain sounds, but that’s another issue)