It’s not needed at all, although it does help a bit.
I keybinded most of my keys to the left side of my keyboard:
v=1 x=2 c=3 q=4 e=5
r=F1 t=F2 g=F3 b=F4
1=heal 2= utility 1 3= utility 2 4= utility 3 5= elite
I do use a g502 gaming mouse, but the only things I put on my mouse is the dodge on my thumb button (previously I had it on Shift cause V was in use) and weapon swap on the button next to the left-click button (the original button still works too).
Just expect to button smash a lot and needing some time to adjust to it.