Happens to me, Windows 7 and Windows 10, 2 GTX980s SLI.
Happens when i run EVGA Precision. On windows 7 it makes the game crash as well.
Have tried Yolomouse dose not help. Have to play with EVGA Precision off. Happens in other games as well. There is some bug when running 4k and upscaled icons and fonts as well that makes it happen on Win7, That dose not seem to happen on Win 10..
Oz