I played without a multi-button mouse for a year or so. Just bought a Naga and adjusted my binds to the following:
Naga side buttons bound to Num-Pad keys 1 through 12 to free keyboard up.
Weapon 1 – Q
Weapon 2 – Naga 1
Weapon 3 – Naga 2
Weapon 4 – Naga 3
Weapon 5 – Naga 4
Heal – C
Utility 1 – Naga 5
Utility 2 – Naga 6
Utility 3 – Naga 7 (will re-map this as it’s a bit of a kitten to hit atm)
Elite – E
Shatters – 1, 2, 3, 4, 5v
Movement – WASD
Dodge – Shift
About Face – Caps Lock
Autorun – Naga 12
Swap Weapon – Mouse Wheel Right
Stow Weapon – Mouse Wheel Left
Interact – X
Look Behind – \
Map – Naga 11
Highlight Items – Left Ctrl
Highlight NPC – Left Alt
Inventory – B (bag)
Hero Panel – H
F – Set to an additional emergency blink button whilst I get adjusted to the Naga!