I only have 2 problems with grenades and neither of them are the fact that it’s ground targeted or no auto attack.
1) I hate how I’m forced to only strafe right when using grenades since I have to take my finger off my movement keys to press 1. I only have a few buttons on my mouse and I’ve bound them to the utility skills which is very comfortable for all classes. If we can bind mouse1 to attack 1 I think it would handle much better.
2) They travel in a curve but you need direct LOS to throw them. This is more apparent when defending in WvW. I have a weapon that allows me to do damage without direct LOS but to use them I have to expose myself :/