Guild Wars 2

Here is a build that I threw together with all Lyssa Runes

http://gw2buildcraft.com/calculator/guardian/?3.0|1.1g.h1|2.1c.h1|1n.7i.1n.7i.1c.7i.1n.7i.1g.7i.1n.7i|2s.e13.2v.e13.3v.d19.3v.e16.2s.e13.2s.d13|0.a2.u46b.u28b.0|55.1|w.17.18.19.1i|e

I agree with Kjeldoran.
Also, Lyssa runes paired with save yourselves is amazing! Save yourselves takes all conditions from your team and using elite with lyssa runes will remove all your conditions and give you 8 boons.
You can completely wipe conditions from your team and its a stun breaker.
I was in WvW yesterday in a big zerg fight. We rushed in and after about 5 seconds I used save yourselves. I received a ton of conditions(from my whole zerg) then removed them all with my elite plus broke my stun. That is priceless because now my whole zerg is free of initial conditions and I am not caught in the middle stunned and dead

I have a similar build using a different armor set up.
I get the same attack stats but 3k armor and 15k health