I do VW everyday or every other day, a few times whenever, with berserker gear and never really have problems unless caught alone with the nasty (usually unseen til too late) teragriff/leecher combo. She seems to excel with the Champion Mordrem Mangler as she has so many ways to destroy pustules really fast.
I find shortbow to be essential for everything except the solo VW bosses, when I sometimes switch to pistols. D/D is my usual melee setup here as it can still cripple multiple enemies in a emergency, if I need to back off and “reset”. ( Things can get dicey quick as we all know)
The best I’ve encountered in online gaming. PvP is probably another matter, but go try APB Reloaded for a toxic community. You’ll have 25 stacks of poison on you in an instant. :p