This is probably the most annoying thing in the game right now, for me, since the option was added to remove right-click select.
A large number of non-attack skills are erroneously triggering an autoATTACK response just because the autoTARGET option is checked in the options.
This causes you to attack the nearest target if you’re wielding a ranged weapon (or melee weapon, if within melee range). In most cases this ends up being the opposite of what you’d like/logically expect to happen. When I invoke Retreat, I don’t want to attack a nearby moa that will cause me to slow down. When I Drop Stimulant, I don’t really want to drop a bandage in a futile attempt to attack a nearby mob. I don’t want my Ranger pet racing off to attack something without being told to do so by me. I don’t want my Necro minions to begin attacking the nearest target, much less aggro things while I’m still in the process of conjuring up the rest of my mini-army. Etc. Etc….
I prefer to have autotargeting on. It’s useful and serves a purpose. I also prefer to be the one that decides when (and what) to attack.