I apologise if this is a stupid question but have you bound the skills to the number pad keys?
The game goes by the key rather than the name/function so 1 at the top of the keyboard and 1 on the number pad are two different keys and have to be bound separately. (I actually have all my skills bound to both, although in a slightly different arrangement, as I wasn’t sure I’d like using the number pad at first so I didn’t want to simply overwrite the defaults.)
If that’s not the issue it would be helpful if you could give us more detail on what kind of trouble you’re having. Are you struggling to find a layout that’s comfortable for you? Or do you mean nothing happens when you press the button?
What I’m trying to do is rather than use the 1-0 that run adjacent to qwerty I want to use the number pad on the right. My trouble is I can’t seem to use the number pad at all in-game, I tested it by trying to type numbers into the chat but had no result. I had a similar lack of result when I went to reassign the keys.